The whole road network of the island is perfectly organized and the transportation from the city of Herakleion and throughout the whole Crete to Agios Nikolaos, is in a frequent basis. By airplane Agios Nikolaos is connected with the rest of Greece and the rest of the world, through the international airport "Nikos Kazantzakis" in Herakleion.
The prefecture of Lassithi has its own Shipping Company named LANE. Its ship "Vincent Cornaros" connects the ports of Agios Nikolaos, Siteia with Peiraias and other island of the Aegean.

Its quite easy to get to Agios Nikolaos which is approximately an hour away from Herakleion (60 kilometers), an hour and a half from Siteia (70 kilometres) and approximately 45 minutes from Ierapetra (36 kilometres).

Agios Nikolaos has no airport but as mentioned it takes less than an hour to get to the airport in Herakleion. There are ships going to Peiraia (Athens) and during the summer ships going to the island of Rhodes. There is also a way to travel from Agios Nikolaos to the Cyclades, to the island of Kasos, Karpathos and Ko.

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